Multidimensional encoding of movement and contextual variables by rat globus pallidus neurons during a novel environment exposure task.

ABSTRACT: The basal ganglia (BG) play a critical role in a variety of functions that are essential for animal survival. Information from different cortical areas propagates through the BG in anatomically segregated circuits along the parallel direct and indirect pathways. We examined how the globus pallidus (GP), a nucleus within the indirect pathway, encodes input from the motor and cognitive domains. We chronically recorded and analyzed neuronal activity in the GP of male rats engaged in a novel environment exposure task. GP neurons displayed multidimensional responses to movement and contextual information. A model predicting single unit activity required many task-related behavioral variables, thus confirming the multidimensionality of GP neurons. In addition, populations of GP neurons, but not

SUBMITTER: Peer ND 

PROVIDER: S-EPMC9475330 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature