Long-term Outcomes Among Men Undergoing Active Surveillance for Prostate Cancer in Sweden.

ABSTRACT:

Importance

The long-term outcomes among men with prostate cancer (PC) whose disease is managed with active surveillance (AS) remains unknown.

Objective

To develop a simulation model with a 30-year follow-up for men with PC managed with AS.

Design, setting, and participants

In this cohort study, a state transition model was created using data from Prostate Cancer data Base Sweden (PCBaSe) on 23 655 men diagnosed with PC and managed with deferred treatment to estimate treatment trajectories. A simulation was performed with 100 000 men in each combination of age at diagnosis, Charlson Comorbidity Index, and PC risk with a follow-up of 30 years.

Main outcomes and measures

Death from PC and death from other causes were estimated, and the proportion of time without a

SUBMITTER: Ventimiglia E 

PROVIDER: S-EPMC9475386 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature