Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis: A Bidirectional 2-Sample Mendelian Randomization Study.

ABSTRACT:

Importance

Psoriasis, psoriatic arthritis, and inflammatory bowel disease, ie, Crohn disease and ulcerative colitis, are chronic systemic immune-mediated disorders affecting an increasing proportion of adults and children worldwide. Observational studies have suggested an association between inflammatory bowel disease and psoriasis and vice versa. So far, however, it remains unclear whether and in which direction causal relationships exist.

Objective

To investigate the association between inflammatory bowel disease, particularly Crohn disease and ulcerative colitis, and psoriasis or psoriatic arthritis.

Design, setting, and participants

A bidirectional 2-sample mendelian randomization study was conducted using summary statistics from genome-wide association studies in

SUBMITTER: Freuer D 

PROVIDER: S-EPMC9475439 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature