Cerenkov luminescence imaging of interscapular brown adipose tissue using a TSPO-targeting PET probe in the UCP1 ThermoMouse.

ABSTRACT: Rationale: [¹⁸F]fluorodeoxyglucose-positron emission tomography ([¹⁸F]FDG-PET) has been widely used as an imaging technique to measure interscapular brown adipose tissue (iBAT) activity. However, it is challenging to obtain iBAT-specific images using [¹⁸F]FDG-PET because increased uptake of [¹⁸F]FDG is observed in tumors, muscle, and inflamed tissues. Uncoupling protein 1 (UCP1) in the mitochondrial membrane, a well-known molecular marker of BAT, has been proposed as a useful BAT imaging marker. Recently, the UCP1 ThermoMouse was developed as a reporter mouse for monitoring UCP1 expression and investigating BAT activation. In addition, Translocator protein-18 kDa (TSPO) located in the outer mitochondrial membrane is also overexpressed in B

SUBMITTER: Lee SY 

PROVIDER: S-EPMC9475450 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature