Early neonatal heart rate variability patterns in different subtypes of perinatal hypoxic-ischemic brain injury.

ABSTRACT:

Background

This study aims to compare the longitudinal changes in heart rate variability (HRV) during therapeutic hypothermia in neonates with different subtypes of hypoxic-ischemic brain injury.

Methods

HRV was computed from 1 hour time-epochs q6 hours for the first 48 hours. Primary outcome was brain-injury pattern on MRI at 4(3-5) days. We fitted linear mixed-effect regression models with HRV metric, brain injury subtype and postnatal age.

Results

Among 89 term neonates, 40 neonates had abnormal brain MRI (focal infarct 15 (38%), basal-ganglia predominant 8 (20%), watershed-predominant 5 (13%), and mixed pattern 12 (30%)). There was no significant difference in the HRV metrics between neonates with normal MRI, focal infarcts and basal ganglia pattern. At any given

SUBMITTER: Goswami I 

PROVIDER: S-EPMC9475489 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature