Programmable Drug Release from a Dual-Stimuli Responsive Magnetic Metal-Organic Framework.

ABSTRACT: Along with the increasing incidence of cancer and drawbacks of traditional drug delivery systems (DDSs), developing novel nanocarriers for sustained targeted-drug release has become urgent. In this regard, metal-organic frameworks (MOFs) have emerged as potential candidates due to their structural flexibility, defined porosity, lower toxicity, and biodegradability. Herein, a FeMn-based ferromagnetic MOF was synthesized from a preassembled Fe₂Mn(μ₃-O) cluster. The introduction of the Mn provided the ferromagnetic character to FeMn-MIL-88B. 5-Fluoruracil (5-FU) was encapsulated as a model drug in the MOFs, and its pH and H₂S dual-stimuli responsive controlled release was realized. FeMn-MIL-88B presented a higher 5-FU loading capacity of 43.8 wt % and rapid dr

SUBMITTER: Akbar MU 

PROVIDER: S-EPMC9475617 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature