Investigation of the role of polymorphic variants FTO gene in schizophrenia patients with metabolic syndrome

ABSTRACT:

Introduction

Medication is primary tactics in schizophrenia treatment. First and second generation antipsychotics (FGA and SGA respectively) affect on core symptoms. Unfortunately, it causes side effects. Metabolic syndrome one of them and includes large number of affections like body mass index changes, lipidemias, hypertension and others.

Objectives

To study the role of polymorphic variants FTO gene in metabolic syndrome in schizophrenia patients.

Methods

We were investigated 480 patients. Main criteria for inclusion in study was using antipsychotics, verified diagnosis of schizophrenia and metabolic syndrome. Mean age was 42,1±1,4 years. The metabolic syndrome was assessment based on clinical data. Standard phenol-chloroform protocol for DNA isolation was used

SUBMITTER: Pozhidaev I 

PROVIDER: S-EPMC9475723 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature