Computational Insights into the Regeneration of Ovothiol and Ergothioneine and Their Selenium Analogues by Glutathione.

ABSTRACT: Ovothiol and ergothioneine are powerful antioxidants that readily react with oxidants by forming their respective disulfides. In fact, ovothiol is widely considered one of the most powerful natural antioxidants. However, for these antioxidants to be again involved in reacting with oxidants, they must be regenerated via the reduction of the disulfide bonds. In the present work, the regeneration of the antioxidants ovothiol and ergothioneine and their selenium analogues, by the closed-shell nucleophilic attack of glutathione, was investigated using density functional theory. From the calculated thermodynamic data, the attack of glutathione on OSSO and EYYE (where Y = S and/or Se) will readily occur in solution. Moreover, in comparison to the reference reaction GSH + GSSG → GSSG + GSH, all re

SUBMITTER: Elder JB 

PROVIDER: S-EPMC9476190 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature