Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform.

ABSTRACT: The tumor microenvironment (TME) is a complex network of non-malignant cells and stroma that perform a wide array of vital roles in tumor growth, immune evasion, metastasis, and therapeutic resistance. These highly diverse roles have been shown to be critically important to the progression of cancers and have already shown potential as therapeutic targets. Therefore, there has been a tremendous push to elucidate the pathways that underlie these roles and to develop new TME-directed therapies for cancer treatment. Unfortunately, TME-focused research has been limited by a lack of translational in vitro culture platforms that can model this highly complex niche and can support the integrated analysis of cell biology and function. In the current study, we investigate whether an independently d

SUBMITTER: Sethakorn N 

PROVIDER: S-EPMC9476232 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature