Ontology highlight
ABSTRACT:
SUBMITTER: Cao X
PROVIDER: S-EPMC9476467 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Cao Xia X Maruyama Junki J Zhou Heyue H Fu Yanwen Y Kerwin Lisa L Powers Colin C Sattler Rachel A RA Manning John T JT Singh Alok A Lim Reyna R Healy Laura D LD Johnson Sachi S Paz Cabral Elizabeth E Li Donghui D Lu Lucy L Ledesma Arthur A Lee Daniel D Richards Susan S Rivero-Nava Laura L Li Yan Y Shen Weiqun W Stegman Karen K Blair Benjamin B Urata Shinji S Kishimoto-Urata Magumi M Ko Jamie J Du Na N Morais Kyndal K Lawrence Kate K Rivera Ianne I Pai Chin-I CI Bresson Damien D Brunswick Mark M Zhang Yanliang Y Ji Henry H Paessler Slobodan S Allen Robert D RD
Scientific reports 20220915 1
Coronavirus disease 2019 (COVID-19) continues to significantly impact the global population, thus countermeasure platforms that enable rapid development of therapeutics against variants of SARS-CoV-2 are essential. We report use of a phage display human antibody library approach to rapidly identify neutralizing antibodies (nAbs) against SARS-CoV-2. We demonstrate the binding and neutralization capability of two nAbs, STI-2020 and STI-5041, against the SARS-CoV-2 WA-1 strain as well as the Alpha ...[more]