Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry: A Strategy for Optimization, Characterization, and Quantification of Antioxidant Nitro Derivatives.

ABSTRACT: As an antioxidant, N-phenyl-β-naphthylamine (PBNA) inhibits the activity of oxidants, such as NO _x , to prevent the degradation of energetic materials. In the presence of NO _x , nitrated products can be generated in the process potentially. To characterize nitrated PBNA in a nontargeted analysis of complex samples as such, liquid chromatography tandem quadrupole time-of-flight (LC-QTOF), as an excellent analytic technique, is used due to its high resolution and sensitivity. However, a systematic approach of instrumentation optimization, data interpretation, and quantitative determination of products is needed. Through a step-by-step evaluation of the instrumental parameters used in the Q0, Q1, and Q2 compartments of LC-QTOF, optimal ion yields of

SUBMITTER: Chen K 

PROVIDER: S-EPMC9476526 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature