Brain connectomes in youth at risk for serious mental illness: an exploratory analysis.

ABSTRACT:

Background

Identifying early biomarkers of serious mental illness (SMI)-such as changes in brain structure and function-can aid in early diagnosis and treatment. Whole brain structural and functional connectomes were investigated in youth at risk for SMI.

Methods

Participants were classified as healthy controls (HC; n = 33), familial risk for serious mental illness (stage 0; n = 31), mild symptoms (stage 1a; n = 37), attenuated syndromes (stage 1b; n = 61), or discrete disorder (transition; n = 9) based on clinical assessments. Imaging data was collected from two sites. Graph-theory based analysis was performed on the connectivity matrix constructed from whole-brain white matter fibers derived from constrained spherical deconvolution of the diffusion tensor imaging (DTI) sca

SUBMITTER: Metzak PD 

PROVIDER: S-EPMC9476574 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature