Shared genetic architecture between the two neurodegenerative diseases: Alzheimer's disease and glaucoma.

ABSTRACT:

Background

Considered as the representatives of neurodegenerative diseases, Alzheimer's disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic and environmental risk factors and cause irreversible damages. Current research indicates that there are common features between AD and glaucoma in terms of epidemiology and pathophysiology. However, the understandings and explanations of their comorbidity and potential genetic overlaps are still limited and insufficient.

Method

Genetic pleiotropy analysis was performed using large genome-wide association studies summary statistics of AD and glaucoma, with an independent cohort of glaucoma for replication. Conditional and conjunctional false discovery rate methods were applied to identify the shared lo

SUBMITTER: Zheng C 

PROVIDER: S-EPMC9476600 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature