Analgesic alkaloids from Urticae Fissae Herba.

ABSTRACT:

Objective

To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis.

Methods

The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified by comprehensive spectroscopic analysis.

Results

Thirteen alkaloids (1-13), two lignans (14, 15), and three amides (16-18) were isolated from the active fractions. Among them, compound 1 was a new alkaloid, and compound 6 was a new natural product. The activity evaluation in vivo indicated that various pyrrole alkaloids (1, 3, 6, and 12) possessed significant analgesic ac

SUBMITTER: Feng X 

PROVIDER: S-EPMC9476718 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature