Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition.

ABSTRACT:

Objective

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP⁺-induced PD models in vivo and in vitro. It is necessary to evaluate the efficacy of the anti-PD effects under various models.

Methods

In the present study, total chemical synthesis was used to obtain KuA, which performed low content in Lycii Cortex. Then, 6-OHDA-induced PD model of PC12 cells was used to investigate the effects of KuA on PD.

Results

Our results demonstrated that KuA ameliorated cell loss and mitochondrial membrane potential (MMP) loss, and inhibited Bax/Bcl-2 ra

SUBMITTER: Li X 

PROVIDER: S-EPMC9476749 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature