Dataset Information

Preparation and pharmacokinetics in vivo of linarin solid dispersion and liposome.

ABSTRACT:

Objective

The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin.

Methods

Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the solvent method and the thin film hydration method respectively. The Transwell chamber model of Caco-2 cells was established to evaluate the absorption of drug. The pharmacokinetics of linarin, LSD and LL in rats after ig administration were carried out by high performance liquid chromatography (HPLC) method.

Results

The solubility of LSD and LL was severally 3.29 times and 3.09 times than that of linarin. The permeation coefficients of LSD and LL were greater than 10^-6, indicating that the absorption of LSD and LL were both better than linarin. The bioavailability of the LSD was 3.363 times higher than that of linarin, and the bioavailability of LL was 0.9886 times higher than that of linarin.

Conclusion

The linarin was more suitable for making solid dispersion to enhance its solubility and bioavailability.

SUBMITTER: Huang Y

PROVIDER: S-EPMC9476784 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Preparation and pharmacokinetics <i>in vivo</i> of linarin solid dispersion and liposome.

Huang Yingying Y Xu Lihua L Zhang Fangping F Liu Yang Y Wang Yunyu Y Meng Fangfeng F Li Shuang S Cheng Xintao X Bi Yuefeng Y

Chinese herbal medicines 20220402 2

<h4>Objective</h4>The current investigation aimed to determine the appropriate dosage form by comparing solid dispersion and liposome to achieve the purpose of improving the solubility and bioavailability of linarin.<h4>Methods</h4>Linarin solid dispersion (LSD) and linarin liposome (LL) were developed via the solvent method and the thin film hydration method respectively. The Transwell chamber model of Caco-2 cells was established to evaluate the absorption of drug. The pharmacokinetics of lina ...[more]

PMID: 36117666

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