Albumin administration in patients with cirrhosis: Current role and novel perspectives.

ABSTRACT: Mortality in cirrhosis is mostly associated with the development of clinical decompensation, characterized by ascites, hepatic encephalopathy, variceal bleeding, or jaundice. Therefore, it is important to prevent and manage such complications. Traditionally, the pathophysiology of decompensated cirrhosis was explained by the peripheral arterial vasodilation hypothesis, but it is currently understood that decompensation might also be driven by a systemic inflammatory state (the systemic inflammation hypothesis). Considering its oncotic and nononcotic properties, albumin has been thoroughly evaluated in the prevention and management of several of these decompensating events. There are formal evidence-based recommendations from international medical societies proposing that albumin be adminis

SUBMITTER: de Mattos AZ 

PROVIDER: S-EPMC9476855 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature