Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer.

ABSTRACT:

Background

Anoctamin 5 (ANO5)/transmembrane protein 16E belongs to the ANO/ transmembrane protein 16 anion channel family. ANOs comprise a family of plasma membrane proteins that mediate ion transport and phospholipid scrambling and regulate other membrane proteins in numerous cell types. Previous studies have elucidated the roles and mechanisms of ANO5 activation in various cancer types. However, it remains unclear whether ANO5 acts as a plasma membrane chloride channel, and its expression and functions in gastric cancer (GC) have not been investigated.

Aim

To examine the role of ANO5 in the regulation of tumor progression and clinicopathological significance of its expression in GC.

Methods

Knockdown experiments using ANO5 small interfering RNA were conducted in hum

SUBMITTER: Fukami T 

PROVIDER: S-EPMC9476871 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature