Lack of association between SOCS3 and SOCS7 polymorphisms and psoriasis.

ABSTRACT:

Background

Psoriasis is a common, chronic, inflammatory skin disease that involves changes taking place as a result of activation of the immune system. Suppressor of cytokine signaling proteins (SOCS) are intracellular proteins that act as endogenous inhibitors of proinflammatory pathways triggered by various cytokines. In this study, the relationship between psoriasis disease and SOCS gene polymorphisms is investigated in relation to the pathogenesis of psoriasis to clarify the psoriasis susceptibility profile.

Methods

The SOCS3 rs4969169 and SOCS7 rs3748726 polymorphisms were detected using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The study was approved by the Clinical Research Ethics Committee of Bulent Ecevit University an

SUBMITTER: Ozcep M 

PROVIDER: S-EPMC9476888 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature