Cold atmospheric plasma driven self-assembly in serum proteins: insights into the protein aggregation to biomaterials.

ABSTRACT: The self-assembly of proteins is crucial in many biomedical applications. This work deals with understanding the role of cold atmospheric plasma (CAP) on the self-assembly of two different proteins present in the serum - BSA and hemoglobin and to elucidate the process associated with the direct application of physical plasma on or in the human (or animal) body, which has implications in therapeutics. The work has been corroborated by several spectroscopic studies such as fluorescence spectroscopy, circular dichroism spectroscopy, and SEM analysis. Through steady-state fluorescence spectroscopy and by following the tryptophan fluorescence, we observed that the emission intensity was quenched for the protein when treated with plasma radiation. Circular dichroism spectroscopy revealed that th

SUBMITTER: Khanikar RR 

PROVIDER: S-EPMC9476907 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature