Neurofilament light as a biomarker for motor decline in Parkinson's disease.

ABSTRACT:

Objectives

The aim of this study was to determine whether neurofifilament light (NfL) could reflect motor decline and compare the predictive values of cerebrospinal fluid (CSF) and serum NfL in individuals with PD.

Methods

CSF/serum samples were collected from patients with PD and healthy controls (HCs) with motor assessments at baseline and after three years of follow-up from the Parkinson's Progression Markers Initiative (PPMI). Multiple linear regression models and linear mixed-effects models were used to investigate the associations of motor assessments with baseline and longitudinal CSF/serum NfL. Associations between the change rates of motor assessments and CSF/serum NfL were further investigated via multiple linear regression models. Mediating effect analysis

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9477093 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature