Haemophilus influenzae serotype b seroprevalence in central Lao PDR before and after vaccine introduction.

ABSTRACT:

Introduction

Vaccination has dramatically reduced invasive Haemophilus influenzae type b (Hib) disease worldwide. Hib vaccination was introduced in the Lao PDR in 2009, as part of the pentavalent vaccine. To contribute to the understanding of the epidemiology of Hib in Lao PDR and the protection levels before and after the introduction of the vaccination, we tested serum samples from existing cohorts of vaccine age-eligible children and unvaccinated adolescents for antibodies against Hib.

Methods

Serum samples from 296 adolescents born before vaccine introduction and from 1017 children under 5 years (vaccinated and unvaccinated) were tested for anti-Hib antibodies by ELISA. Bivariate analyses were performed to investigate factors associated with long-term protection.

Resu

SUBMITTER: Hefele L 

PROVIDER: S-EPMC9477263 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature