Determination of the optimum definition of growth evaluation for indeterminate pulmonary nodules detected in lung cancer screening.

ABSTRACT:

Objective

To determine the optimum definition of growth for indeterminate pulmonary nodules detected in lung cancer screening.

Materials and methods

Individuals with indeterminate nodules as defined by volume of 50-500 mm3 (solid nodules) and solid component volume of 50-500 mm3 or average diameter of non-solid component ≥8 mm (part-solid nodules) on baseline lung cancer screening low-dose chest CT (LDCT) were included. The average diameters and volumes of the nodules were measured on baseline and follow-up LDCTs with semi-automated segmentation. Sensitivities and specificities for lung cancer diagnosis of nodule growth defined by a) percentage volume growth ≥25% (defined in the NELSON study); b) absolute diameter growth >1.5 mm (defined in the Lung-RADS version 1.1); and c)

SUBMITTER: Lee JH 

PROVIDER: S-EPMC9477274 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature