Internal plication for spring confinement to lengthen intestine in a porcine model.

ABSTRACT:

Background

Short bowel syndrome and its resultant nutritional deficiencies are the most common cause of intestinal failure. Significant intestinal lengthening using intraluminal springs is feasible in porcine models using an external plication technique. We hypothesize that an internal plication technique will yield significant intestinal lengthening, which may lead to future endoscopic spring placement.

Methods

Uncompressed springs measuring 7.5 cm with a diameter of 1.0 cm were compressed to 2.0 cm. A gelatin-encapsulated compressed nitinol spring was inserted into the jejunal lumen of juvenile pigs and held in place with endoluminal sutures just proximal and distal to the spring-containing segment. A control segment distal to the spring was marked. Pigs were euthanized on

SUBMITTER: Rafeeqi TA 

PROVIDER: S-EPMC9477332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature