Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization.

ABSTRACT: Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot. A small fraction of circulating fibrinogen is the variant γA/γ', which has been associated with high-affinity thrombin binding and implicated as a risk factor for myocardial infarctions, deep vein thrombosis, and coronary artery disease. Thrombin is also known to be strongly sequestered by polymerized fibrin for extended periods of time in a way that is partially regulated by γA/γ'. However, the role of γA/γ'-thrombin interactions during fibrin polymerization is not fully understood. Here, we present a mathematical model of fibrin polymerization that cons

SUBMITTER: Kelley MA 

PROVIDER: S-EPMC9477365 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature