SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis.

ABSTRACT: The ongoing COVID-19 pandemic is a major public health crisis. Despite the development and deployment of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pandemic persists. The continued spread of the virus is largely driven by the emergence of viral variants, which can evade the current vaccines through mutations in the spike protein. Although these differences in spike are important in terms of transmission and vaccine responses, these variants possess mutations in the other parts of their genome that may also affect pathogenesis. Of particular interest to us are the mutations present in the accessory genes, which have been shown to contribute to pathogenesis in the host through interference with innate immune signaling, among other effects on host machi

SUBMITTER: McGrath ME 

PROVIDER: S-EPMC9477415 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature