Brain morphology changes after spinal cord injury: A voxel-based meta-analysis.

ABSTRACT:

Objectives

Spinal cord injury (SCI) remodels the brain structure and alters brain function. To identify specific changes in brain gray matter volume (GMV) and white matter volume (WMV) following SCI, we conducted a voxel-based meta-analysis of whole-brain voxel-based morphometry (VBM) studies.

Methods

We performed a comprehensive literature search on VBM studies that compared SCI patients and healthy controls in PubMed, Web of Science and the China National Knowledge Infrastructure from 1980 to April 2022. Then, we conducted a voxel-based meta-analysis using seed-based d mapping with permutation of subject images (SDM-PSI). Meta-regression analysis was performed to identify the effects of clinical characteristics.

Results

Our study collected 20 studies with 22 GMV dat

SUBMITTER: Yu H 

PROVIDER: S-EPMC9477418 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature