Stage-dependent differential influence of metabolic and structural networks on memory across Alzheimer's disease continuum.

ABSTRACT:

Background

Large-scale neuronal network breakdown underlies memory impairment in Alzheimer's disease (AD). However, the differential trajectories of the relationships between network organisation and memory across pathology and cognitive stages in AD remain elusive. We determined whether and how the influences of individual-level structural and metabolic covariance network integrity on memory varied with amyloid pathology across clinical stages without assuming a constant relationship.

Methods

Seven hundred and eight participants from the Alzheimer's Disease Neuroimaging Initiative were studied. Individual-level structural and metabolic covariance scores in higher-level cognitive and hippocampal networks were derived from magnetic resonance imaging and [¹⁸F] fluor

SUBMITTER: Ng KP 

PROVIDER: S-EPMC9477498 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature