From the original SARS-CoV-2 strain to the Omicron variant: Predictors of COVID-19 in ambulatory symptomatic children.

ABSTRACT:

Objectives

To determine the predictors of a positive SARS-CoV-2 test in a pediatric ambulatory setting.

Patients and methods

We performed a cross-sectional prospective study (November 2020-February 2022) of 93 ambulatory settings in France. We included symptomatic children < 15 years old tested for SARS-CoV-2. For each period corresponding to the spread of the original strain and its variants (period 1: original strain; period 2: Alpha, period 3: Delta; period 4: Omicron), we used a multivariate analysis to estimate adjusted odds ratios (aORs) associated with COVID-19 among age, signs, symptoms or contact, and 95 % confidence intervals (95CIs).

Results

Of 5,336 children, 13.9 % (95CI 13.0-14.8) had a positive test. During the first three periods, the positivity rate r

SUBMITTER: Cohen R 

PROVIDER: S-EPMC9477611 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature