Development and validation of an epithelial-mesenchymal transition-related gene signature for predicting prognosis.

ABSTRACT:

Background

Currently, there are many therapeutic methods for lung adenocarcinoma (LUAD), but the 5-year survival rate is still only 15% at later stages. Epithelial- mesenchymal transition (EMT) has been shown to be closely associated with local dissemination and subsequent metastasis of solid tumors. However, the role of EMT in the occurrence and development of LUAD remains unclear.

Aim

To further elucidate the value of EMT-related genes in LUAD prognosis.

Methods

Univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses were applied to establish and validate a new EMT-related gene signature for predicting LUAD prognosis. The risk model was evaluated by Kaplan-Meier survival analysis, principal component analysis, and functi

SUBMITTER: Zhou DH 

PROVIDER: S-EPMC9477694 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature