Structures and mechanism of the plant PIN-FORMED auxin transporter.

ABSTRACT: Auxins are hormones that have central roles and control nearly all aspects of growth and development in plants^1-3. The proteins in the PIN-FORMED (PIN) family (also known as the auxin efflux carrier family) are key participants in this process and control auxin export from the cytosol to the extracellular space^4-9. Owing to a lack of structural and biochemical data, the molecular mechanism of PIN-mediated auxin transport is not understood. Here we present biophysical analysis together with three structures of Arabidopsis thaliana PIN8: two outward-facing conformations with and without auxin, and one inward-facing conformation bound to the herbicide naphthylphthalamic acid. The structure forms a homodimer, with each monomer divided into a transport and scaffold domain

SUBMITTER: Ung KL 

PROVIDER: S-EPMC9477730 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature