African-specific molecular taxonomy of prostate cancer.

ABSTRACT: Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages¹. The contributing genetic and non-genetic factors, and associated mutational processes, are unknown^2,3. Here, through whole-genome sequencing of treatment-naive prostate cancer samples from 183 ancestrally (African versus European) and globally distinct patients, we generate a large cancer genomics resource for sub-Saharan Africa, identifying around 2 million somatic variants. Significant African-ancestry-specific findings include an elevated tumour mutational burden, increased percentage of genome alteration, a greater number of predicted damaging mutations and a h

SUBMITTER: Jaratlerdsiri W 

PROVIDER: S-EPMC9477733 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature