A condensate dynamic instability orchestrates actomyosin cortex activation.

ABSTRACT: A key event at the onset of development is the activation of a contractile actomyosin cortex during the oocyte-to-embryo transition^1-3. Here we report on the discovery that, in Caenorhabditis elegans oocytes, actomyosin cortex activation is supported by the emergence of thousands of short-lived protein condensates rich in F-actin, N-WASP and the ARP2/3 complex^4-8 that form an active micro-emulsion. A phase portrait analysis of the dynamics of individual cortical condensates reveals that condensates initially grow and then transition to disassembly before dissolving completely. We find that, in contrast to condensate growth through diffusion⁹, the growth dynamics of cortical condensates are chemically driven. Notably, the associated chemical reactions obey m

SUBMITTER: Yan VT 

PROVIDER: S-EPMC9477739 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature