The role of somatosensory innervation of adipose tissues.

ABSTRACT: Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the brain, which integrates peripheral information and regulates adipocyte function through noradrenergic sympathetic output¹. Moreover, somatosensory neurons of the dorsal root ganglia innervate adipose tissue². However, the lack of genetic tools to selectively target these neurons has limited understanding of their physiological importance. Here we developed viral, genetic and imaging strategies to manipulate sensory nerves in an organ-specific manner in mice. This enabled us to visualize the entire axonal projection of dorsal root ganglia from the soma to subcutaneou

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9477745 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature