Organizing structural principles of the IL-17 ligand-receptor axis.

ABSTRACT: The IL-17 family of cytokines and receptors have central roles in host defence against infection and development of inflammatory diseases¹. The compositions and structures of functional IL-17 family ligand-receptor signalling assemblies remain unclear. IL-17E (also known as IL-25) is a key regulator of type 2 immune responses and driver of inflammatory diseases, such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functional responses². Here we studied IL-25-IL-17RB binary and IL-25-IL-17RB-IL-17RA ternary complexes using a combination of cryo-electron microscopy, single-molecule imaging and cell-based signalling approaches. The IL-25-IL-17RB-IL-17RA ternary signalling assembly is a C2-symmetric complex in which the IL-25-IL-17RB

SUBMITTER: Wilson SC 

PROVIDER: S-EPMC9477748 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature