Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy.

ABSTRACT: Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. It has long been known that autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses, leading to excessive and uncontrol tissue inflammation. The dysregulation of epigenetic alterations including DNA methylation, posttranslational modifications to histone proteins, and noncoding RNA expression has been implicated in a host of inflammatory disorders and the immune system. The inflammatory response is considered as a critical trigger of epigenetic alterations that in turn intercede inflammatory actions. Thus, understanding the molecular mechanism that

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9477794 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature