Magnetic resonance imaging analysis predicts nanoparticle concentration delivered to the brain parenchyma.

ABSTRACT: Ultrasound in combination with the introduction of microbubbles into the vasculature effectively opens the blood brain barrier (BBB) to allow the passage of therapeutic agents. Increased permeability of the BBB is typically demonstrated with small-molecule agents (e.g., 1-nm gadolinium salts). Permeability to small-molecule agents, however, cannot reliably predict the transfer of remarkably larger molecules (e.g., monoclonal antibodies) required by numerous therapies. To overcome this issue, we developed a magnetic resonance imaging analysis based on the ΔR₂* physical parameter that can be measured intraoperatively for efficient real-time treatment management. We demonstrate successful correlations between ΔR₂* values and parenchymal concentrations of 3 differently si

SUBMITTER: Plaksin M 

PROVIDER: S-EPMC9477799 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature