AC amplification gain in organic electrochemical transistors for impedance-based single cell sensors.

ABSTRACT: Research on electrolyte-gated and organic electrochemical transistor (OECT) architectures is motivated by the prospect of a highly biocompatible interface capable of amplifying bioelectronic signals at the site of detection. Despite many demonstrations in these directions, a quantitative model for OECTs as impedance biosensors is still lacking. We overcome this issue by introducing a model experiment where we simulate the detection of a single cell by the impedance sensing of a dielectric microparticle. The highly reproducible experiment allows us to study the impact of transistor geometry and operation conditions on device sensitivity. With the data we rationalize a mathematical model that provides clear guidelines for the optimization of OECTs as single cell sensors, and we verify the qu

SUBMITTER: Bonafe F 

PROVIDER: S-EPMC9477811 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature