Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality.

ABSTRACT:

Aims/hypothesis

Diabetes is associated with an increased risk of cancer. Prostasin is an epithelial sodium channel stimulator that has been associated with suppression of tumours, glucose metabolism and hyperglycaemia-associated tumour pathology. However, the association between prostasin, diabetes and cancer mortality has not been well investigated in humans. We aim to investigate the associations between plasma prostasin and diabetes, and to explore whether prostasin has an effect on cancer mortality risk in individuals with hyperglycaemia.

Methods

Plasma prostasin was measured using samples from the Malmö Diet and Cancer Study Cardiovascular Cohort, and statistical analysis was performed from both sex-specific quartiles and per 1 SD. The cross-sectional association betwee

SUBMITTER: Bao X 

PROVIDER: S-EPMC9477896 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature