Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study.

ABSTRACT:

Aims/hypothesis

Metformin use has been associated with reduced incidence of dementia in diabetic individuals in observational studies. However, the causality between the two in the general population is unclear. This study uses Mendelian randomisation (MR) to investigate the causal effect of metformin targets on Alzheimer's disease and potential causal mechanisms in the brain linking the two.

Methods

Genetic proxies for the effects of metformin drug targets were identified as variants in the gene for the corresponding target that associated with HbA_1c level (N=344,182) and expression level of the corresponding gene (N≤31,684). The cognitive outcomes were derived from genome-wide association studies comprising 527,138 middle-aged Europeans, including 71,880 with Al

SUBMITTER: Zheng J 

PROVIDER: S-EPMC9477943 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature