Expandable Lung Epithelium Differentiated from Human Embryonic Stem Cells.

ABSTRACT:

Background

The progenitors to lung airway epithelium that are capable of long-term propagation may represent an attractive source of cells for cell-based therapies, disease modeling, toxicity testing, and others. Principally, there are two main options for obtaining lung epithelial progenitors: (i) direct isolation of endogenous progenitors from human lungs and (ii) in vitro differentiation from some other cell type. The prime candidates for the second approach are pluripotent stem cells, which may provide autologous and/or allogeneic cell resource in clinically relevant quality and quantity.

Methods

By exploiting the differentiation potential of human embryonic stem cells (hESC), here we derived expandable lung epithelium (ELEP) and established culture conditions for their

SUBMITTER: Kotasova H 

PROVIDER: S-EPMC9478014 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature