Water-soluble tomato concentrate modulates shear-induced platelet aggregation and blood flow in vitro and in vivo.

ABSTRACT: Water-soluble tomato concentrate (WSTC), extracted from mature tomatoes, is the first health product in Europe that has been approved "to help maintain normal platelet activity to maintain healthy blood flow." We hypothesized that WSTC might exert an influence on blood flow shear stress-induced platelet aggregation (SIPA) and in turn maintains healthy blood flow. We used a microfluidic system to measure the effects of WSTC on SIPA in vitro. We also used the strenuous exercise rat model and the κ-carrageenan-induced rat tail thrombosis model to demonstrate the effects of WSTC on blood flow. WSTC significantly inhibited platelet aggregation at pathological high shear rate of 4,000 s^-1 and 8,000 s^-1 in vitro (P < 0.05 or P < 0.01). WSTC reduce

SUBMITTER: Liu L 

PROVIDER: S-EPMC9478107 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature