Evaluating the effect of tanning response to sun exposure on the risk of skin diseases through Mendelian randomization.

ABSTRACT: Background: Until now, the relevance of the tanning response to sun exposure and skin diseases has incomplete and inconsistent epidemiological observations. In this case, it is valuable to find out the causality of tanning response to sun exposure and skin diseases, and take a step further toward developing effective therapies as well as prevention methods. Methods: We investigated the causal effect of tanning response to sun exposure on 10 major skin diseases that have been studied in recent large-scale genome-wide association studies (GWASs). Significant independent genetic variants from large-scale GWAS on ease of skin tanning (N = 453,065) are selected as the effective instrumental variables (IVs). For each skin disease, we extracted the summary statistics of those IVs (o

SUBMITTER: Ping W 

PROVIDER: S-EPMC9478173 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature