Rapid determination of the total content of oleanolic acid and ursolic acid in Chaenomelis Fructus using near-infrared spectroscopy.

ABSTRACT: Chaenomelis Fructus is a widely used traditional Chinese medicine with a long history in China. The total content of oleanolic acid (OA) and ursolic acid (UA) is taken as an important quality marker of Chaenomelis Fructus. In this study, quantitative models for the prediction total content of OA and UA in Chaenomelis Fructus were explored based on near-infrared spectroscopy (NIRS). The content of OA and UA in each sample was determined using high-performance liquid chromatography (HPLC), and the data was used as a reference. In the partial least squares (PLS) model, both leave one out cross validation (LOOCV) of the calibration set and external validation of the validation set were used to screen spectrum preprocessing methods, and finally the multiplicative scatter correction (MSC) was ch

SUBMITTER: Ming J 

PROVIDER: S-EPMC9478200 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature