Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma.

ABSTRACT:

Background

Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma, a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered the most common congenital tumor in the skull. Therefore, this article aims to identify hub genes that might serve as genetic markers of diagnosis, treatment, and prognosis of ACP.

Methods

The procedure of this research includes the acquisition of public data, identification and functional annotation of differentially expressed genes (DEGs), construction and analysis of protein-protein interaction network, and the mining and analysis of hub genes by Spearman-rho test, multivariable linear regression, and receiver operator characteristic curve analysis. Quanti

SUBMITTER: Zou YF 

PROVIDER: S-EPMC9478218 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature