Pausing TPN to Decrease Abnormal Newborn Screens: A NICU Quality Initiative.

ABSTRACT: Detection of metabolic and genetic disorders via the newborn screen (NBS) remains a great diagnostic achievement in medicine. Unfortunately, many false positives for neonates due to acute illness lead to repeat testing. For example, the rate of abnormal NBS in very low birth weight (VLBW) neonates at the University of Virginia was 66%, with 23% due to total parenteral nutrition (TPN) on the amino acid profile.

Methods

This study describes a quality improvement (QI) initiative completed in the NICU at a quaternary care center. The primary and secondary outcomes were the percentage of abnormal NBSs in VLBWs and all admissions. The intervention required a pause in TPN, and a dextrose-containing fluid ran for 4 hours before collecting the NBS. During PDSA cycle 1, the TPN pause occurred

SUBMITTER: Wiggins JB 

PROVIDER: S-EPMC9478258 | biostudies-literature | 2022 Sep-Oct

REPOSITORIES: biostudies-literature