Inflammatory bowel disease and cardiovascular disease: A two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Although epidemiological studies have shown a positive relationship between inflammatory bowel disease (IBD) and risk of cardiovascular disease (CVD) outcomes, a solid causal relationship has not been established. Thus, a two-sample Mendelian randomization (MR) study was conducted to explore the potential causal effect between IBD and CVD outcomes.

Methods

We performed a two-sample MR analysis to analyze the causal effect of the IBD on CVD outcome by using summary-level genome-wide association studies of European descent. The inverse-variance weighted (IVW) method was used as the main MR analysis, with complementary analyses of MR Egger, maximum likelihood, weighted median, penalized weighted media, simple mode, weighted mode, and MR-PRESSO methods. Multiple sensi

SUBMITTER: Wu K 

PROVIDER: S-EPMC9478388 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature