TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy.

ABSTRACT: Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each other. The molecular and cellular pathways involved are multifactorial and complex, including peripheral and central components. Peripherally, pain and itch are produced by subpopulations of specialized nociceptors that recognize and transduce algesic and pruritogenic signals. Although still under intense investigation, cumulative evidence is pointing to the thermosensory channel TRPV1 as a hub for a large number of pro-algesic and itchy agents. TRPV1 appears metabolically coupled to most neural receptors that recognize algesic and pruritic mol

SUBMITTER: Fernandez-Carvajal A 

PROVIDER: S-EPMC9478410 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature