Systemic lupus erythematosus and the risk of cardiovascular diseases: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Previous observational studies have suggested that the causal role of systemic lupus erythematosus (SLE) in the risk of cardiovascular diseases (CVDs) remained inconsistent. In this study, we aimed to investigate the causal relationship between SLE and CVDs by two-sample Mendelian randomization (MR) analysis.

Methods

Genetic instruments for SLE were obtained from a public genome-wide association study (GWAS) with 4,036 patients with SLE and 6,959 controls. Summary statistical data for CVDs, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), ischemic stroke (IS), and its subtypes, were identified from other available GWAS meta-analyses. The inverse-variance weighted (IVW) method was used as the primary method to estimate

SUBMITTER: Huang S 

PROVIDER: S-EPMC9478435 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature