Soluble programmed cell death-ligand 1 as a new potential biomarker associated with acute coronary syndrome.

ABSTRACT:

Background

Soluble programmed cell death-ligand 1 (sPD-L1) has been well documented to activate immunosuppression and is considered an essential predictor of negative clinical outcomes for several malignances and inflammatory conditions. However, the clinical significance of sPD-L1 in the peripheral blood of patients with coronary artery disease (CAD) remains unclear. The aim of this study was to assess the correlations of sPD-L1 with clinical features in CAD patients and evaluate the diagnostic value of this protein in CAD.

Methods

A total of 111 CAD patients and 97 healthy volunteers who served as healthy controls (HCs) were consecutively enrolled. Plasma levels of sPD-L1 were measured with an amplified enzyme-linked immunosorbent assay (ELISA), and hs-CRP was measured wit

SUBMITTER: Li S 

PROVIDER: S-EPMC9478490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature